L'Actu de BNMI
- Poursuite des séminaires de BNMI avec plusieurs interventions au programme. En 2015 : une première série de séminaires alternant les thématiques "vasculaire" et "mitochondrie"
Lancement cette année de PREMMI avec l'accueil de Guy Lenears, DR2 CNRS (à BNMI depuis le 1/1/2015)
Department of Integrated Neurovascular and Mitochondrial Biology
INSERM UMR 1083 – CNRS UMR 6214 (BNMI - Biologie Neurovasculaire et Mitochondriale Intégrée)
Head of Department : Cloaking , PharmD, PhD.
The laboratory has a long history of research on vascular tone and resistance arteries and especially on myogenic tone and flow (shear stress)-mediated dilation and remodeling (aims 1 and 3). Myogenic tone and flow-mediated dilation involves local neuroeffector systems such as the renin-angiotensin system and the purinergic system, both involve in physiological response as well as in most vascular disorders (aim 2). This basic research is associated with clinical research performed by several groups investigating microvascular disorders such as lower-limb ischemia in patients (aim 5). We are also associated with the Institute for Biomedical Problems in Moscow, Russia (CNRS-CNES joint laboratory project) for the investigation of vascular disorders induced by physical inactivity and environmental stress (aim 4).
Over the past few years, we have investigated the age-related changes in the remodeling and tone of resistance arteries associated with obesity and diabetes (aim 3). This has led to several collaborative studies with the group studying mitochondrial energetics in Angers and finally to a common project. The risk factors affecting vascular homeostasis during aging, such as obesity, diabetes and hypertension, involve changes in mitochondrial function leading to excessive oxidative stress and endothelial dysfunction (aims 9 and 10). In contrast, “protective” factors, such as estrogens and plant polyphenols, protect the endothelium, at least partially, through their effect on mitochondria (aim 3 and 8). Thus, we now investigate endothelium dysfunction in aging, focusing on mitochondrial energetics. Among the main risk factors involved in vascular aging we investigate the consequences of a chronic stress and the role of adrenal chromaffin cells (aim 7) and thyroid hormones (aim 6), which greatly influence vascular homeostasis and mitochondrial bioenergetics. We also investigate the epigenetic changes affecting vascular tone in offspring from mothers submitted to risk factors (aim 11, june 2011).
LUNAM (Nantes, Angers and Le Mans University), University of Angers, University Hospital of Angers
National Institut for Health and Medical Research (INSERM)
National Center for Scientific Research (CNRS)